Endocrine Abstracts

Objective: Oxidative stress has been implicated in the pathogenesis of hyperthyroidism, and its complications. Advanced glycation end products (AGEs), compounds derived from non-enzymatic transformation of macromolecules, are able to increase oxidative stress and promote inflammation and are increased in several oxidative stress-related disorders, including autoimmune thyroiditis. In the same diseases, the activity of paraoxonase-1 (PON-1), an anti-oxidant enzyme protecting ag...

Objective: Oxidative stress has been implicated in the pathogenesis of several immune-mediated disorders, including autoimmune thyroid disease. Aim of our study was to investigate the relationship between dietary habit and redox homeostasis, in relationship with thyroid autoimmunity.Materials and methods: We enrolled 200 healthy subjects (173 F, mean age 35 ± 12). None of them was under any pharmacological treatment. Exclusion criteria: any infectio...

Background: PCBs are persistent organic pollutants, able to affect thyroid function (endocrine disruptors) and promote inflammation through multiple mechanisms. The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor able to bind dioxins and dioxin-like pollutants including PCBs, play a key role in xenobiotic response, by up-regulating specific responsive genes, the so-called “AhR gene battery”, including cytochrome P450 1A1 (CYP1A1) and Nuclear ...